Popular Articles
Teeth Whitening

Surgery, Oral Devices Associated With Improvement In Sleep Breathing Disorder
Treatment with surgery or an oral appliance that adjusts the jaw is associated with improvements in obstructive sleep apnea, a condition caused by blocked upper airways in which patients periodically stop breathing during sleep, according to two reports in the May issue of Archives of Otolaryngology-Head & Neck Surgery, one of the JAMA/Archives journals.
generic viagra online
A Single Atom Makes A Big Difference To Purer Water
By substituting a single atom in a molecule widely used to purify water, researchers at Sandia National Laboratories have created a far more effective decontaminant with a shelf life superior to products currently on the market.
plastic surgery before after
News of the day
Non-Wovens As Scaffolds For Artificial Tissue
In future, cartilage, tendon and blood vessel tissue will be produced in the laboratory, with cells being grown on a porous frame, such as non-wovens. A new software program helps to characterize and optimize the non-wovens.
Nutrition

Bacteria Can Induce A Harmful Immune Response

Molecules known as type I IFNs are a central component of the protective immune response following infection with a virus. In contrast, these molecules are not normally linked to the protective immune response following infection with the bacterium Staphylococcus aureus, which is becoming a major health problem due to the emergence of methicillin-resistant (MRSA) strains. However, Alice Prince and colleagues have now determined that Staphylococcus aureus induce the production of type I IFNs by mouse and human airway cells, but these molecules are not part of a protective immune response in mice, rather they markedly enhance the severity of the pneumonia caused by Staphylococcus aureus infection. In the study, the researchers were able to pin down the Staphylococcus aureus protein that causes mouse and human airway cells to produce type I IFNs, protein A. Further analysis identified the region of protein A responsible, the Xr domain, and determined the importance of the type I IFNs produced - mice lacking the molecule to which most type I IFNs bind were dramatically protected from lethal pneumonia caused by infection with Staphylococcus aureus. As the signaling pathway by which type I IFNs activate their effects is very well defined, the authors suggest that targeting molecules in this pathway might provide a beneficial therapeutic approach for treating pneumonia caused by Staphylococcus aureus infection. TITLE: Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A AUTHOR: Alice Prince Columbia University College of Physicians and Surgeons, New York, New York, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=35879 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):