Categories
Cardiovascular
Diagnostics
Endocrinology
Health Insurance
Medical Devices
Mental Health
Nutrition
Oncology
Public Health
Sexual Health
Popular Articles
Teeth Whitening

Cancer Research Partnership Between UCSF, MMRF To Drive Drug Development
The University of California, San Francisco (UCSF) and the Multiple Myeloma Research Foundation (MMRF) have established the Stephen and Nancy Grand Multiple Myeloma Translational Initiative, a research collaboration dedicated to translating basic science discoveries into new candidate drugs for testing in clinical trials.
generic viagra online
Senator Boxer Introduces Legislation To Address Nationwide Nursing Shortage
U.S. Senator Barbara Boxer (D-CA) introduced the National Nursing Reform and Patient Advocacy Act, legislation to protect the rights of nurses to advocate on behalf of their patients, set minimum nurse-to-patient ratios in hospitals, and invest in training nurses to address the current nationwide nursing shortage.
plastic surgery before after
News of the day
What Is The Function Of Lymph Nodes?
If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations - the regions in which the immune response is organised. However, a new paper - published in this week"s issue of PLoS Biology - suggests that lymph nodes are not essential in the mouse in marshalling T-cells (a main immune foot soldier) to respond to a breach of the skin barrier. This result is both surprising in itself, and suggests a novel function for the liver as an alternate site for T-cell activation.
Nutrition

ExonHit Announces Last Patient Out For EHT 0202 Phase IIa Study In Alzheimer's

ExonHit Therapeutics (Paris:ALEHT) announced that clinical testing of EHT 0202, its lead therapeutic compound in Alzheimer"s disease, is progressing well. Final patient dosing for the Phase IIa proof-of-concept clinical trial assessing EHT 0202 in patients with Alzheimer"s disease is completed. "In light of the neuroprotective and procognitive effects demonstrated by EHT 0202 in preclinical studies, we believe that our drug candidate has the potential to modify the course of Alzheimer"s disease and might open a new era in the treatment of this devastating disease," commented Dr. Loö¯c Maurel, President of the Management Board of ExonHit Therapeutics. "We look forward to the outcome of this Phase IIa trial and are planning to initiate out-licensing discussions with potential partners next fall." Top-line data from the EHT 0202/002 Phase IIa study will be presented at the 13th Congress of the European Federation of Neurological Societies on September 14th in Florence, Italy. The study was conducted in 23 centers across France under the supervision of Professor Bruno Vellas, Head of Alzheimer"s Disease Clinical Research Center and Gerontopole, Toulouse University Hospital, France. A total of 197 ambulatory patients suffering from mild to moderate Alzheimer"s disease were selected and 158 of them were randomized to receive oral study treatment over a three-month period. This multicenter, randomized, double-blind, placebo-controlled study was designed to assess the safety and tolerability, as a primary objective, and also exploratory efficacy of EHT 0202 in patients with Alzheimer"s disease. The effect of two different doses of EHT 0202 (either 40 or 80 mg twice a day) as adjunctive therapy to one acetylcholinesterase inhibitor is evaluated in comparison to placebo. Efficacy is evaluated on multiple parameters by using different scales, including a battery of cognitive assessment tests (ADAS-Cog, NTB, MMSE), assessment of patients" daily living activities, and also global behavioural assessment. About EHT 0202 EHT 0202 has a novel mechanism of action when compared to existing Alzheimer"s disease therapeutics: it stimulates the í±-secretase pathway, thus enhancing the production of the procognitive and neuroprotective sAPPí± fragment of APP (Amyloid Precursor Protein). The stimulation of the í±-secretase pathway being to the detriment of Aí² amyloid peptide production, EHT 0202 potentially reduces toxic Aí² plaque formation (1). Phase I studies demonstrated good tolerability of EHT 0202 in both young and aged healthy volunteers; importantly, no sedation was observed clinically. Preclinical studies have shown that EHT 0202 protects cortical neurons against Aí²42-induced stress and that this neuroprotection is associated with sAPPí± induction. EHT 0202 has also demonstrated pro-cognitive properties in several animal models: age-related memory impairment and scopolamine-induced amnesia (2). About Alzheimer"s disease Alzheimer"s disease is a progressive neurodegenerative condition that is the most frequent cause of dementia in the aging population. An estimated 26.6 million people worldwide had Alzheimer in 2006. This number is anticipated to quadruple by 2050 to more than 100 million; 1 in 85 persons worldwide will be living with the disease (3). In France alone, 800,000 people, or 18% of people above 75 years old, have Alzheimer"s disease (4). References (1) Marcade M, Bourdin J, Loiseau N, Peillon H, Rayer A, Drouin D, Schweighoffer F, Desire L. Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing. Journal of Neurochemistry. 2008; 106: 392-404 (2) Pando M, Marcade M, Peillon H, Rayer A, Drouin D, Desire L. An alpha-secretase stimulator drug for cognitive disorders associated with neurodegeneration. Presented at the 12th congress of the European Federation of Neurological Societies; 23-26 August, 2008; Madrid, Spain (3) Brookmeyer R, Johnson E, Ziegler-Graham K, MH Arrighi (July 2007). "Forecasting the global burden of Alzheimer"s disease". Alzheimer"s and Dementia 3 (3): 186-91 (4) Plan Maladie d"Alzheimer 2004-2007- Ministö¨re des solidaritö©s, de la santö© et de la famille ExonHit Therapeutics


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):

© Copyright 2009