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Calixa Therapeutics Announces Initiation Of Phase 2 Clinical Trial Of Its Antibiotic, CXA-101, In Patients With Complicated Urinary Tract Infections
Calixa Therapeutics Inc. today announced the initiation of a Phase 2 clinical trial of CXA-101 in patients with complicated urinary tract infections. CXA-101 is a new broad-spectrum, parenteral cephalosporin antibiotic with excellent in vitro and in vivo activity against Pseudomonas aeruginosa, including drug resistant isolates. Calixa is investigating CXA-101 as a potential treatment for serious bacterial infections in hospitalized patients.
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Impact Of Young Londoners' Alcohol Misuse Revealed, England
The capital"s 11-15 year olds now drink the equivalent of 180,000 bottles of lager every week - and the amount they drink is on the rise, a new report from the London Assembly today warns.
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WFP Appeals For $23M To Help Women, Children In Yemen
The World Food Programme (WFP) issued an urgent appeal on Tuesday for $23 million in "financial support from international donors for food aid to Yemen specifically targeted at women and children," AFP/Google.com reports. The agency said that the "figure represents 42 percent of the 55 million dollars that it needs for the current year to improve the nutrition of more than 1.6 million vulnerable people in Yemen," the news service writes.
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For America's Aged, Surgery At Any Price?

When doctors decide whether or not to go ahead with an expensive surgery, "age is no longer the deciding factor, even for invasive treatment such as open-heart surgery," The Philadelphia Inquirer reports. One question is "whether this never-too-old approach is an example of U.S. medical progress, or an example of why Medicare -- federal health insurance for people over 64 -- is headed for insolvency. The answer, experts say, is both. Which is why the current debate over expanding federal coverage to all uninsured Americans is an ethical and economic minefield. "Forty years ago, it was taken for granted that the elderly were not good candidates for organ transplantation, dialysis, or advanced surgical procedures. That has changed," Daniel Callahan, cofounder of the Hastings Center, a bioethics research institute in Garrison, N.Y., wrote recently. "Under the best of circumstances, age should be irrelevant in the Medicare program. But so far, the cost of care has not been considered, and it can hardly remain irrelevant in a program strapped for money."" In the Philadelphia region, "Medicare pays an average of $40,000 to $60,000, depending on the open-heart procedure, but many elderly suffer complications that can inflate the total. The risks of open-heart surgery, while still substantial, have steadily declined," including for the elderly. In a 2003 study, "for octogenarians, mortality ranged from 7 percent to 11 percent, depending on the procedure." The study found that those odds "are two to three times greater than for patients ages 50 to 79." But "complicating this calculus is the issue of quality of life. Even with advances, surgery and its aftermath are traumatic, especially for elderly with chronic conditions such as diabetes or kidney failure." David Callahan, also cofounder of the Hastings Center says, "I believe it"s gotten harder for doctors to find a bright line between living and dying. Physicians feel compelled to offer heroic measures. They say, "Let"s not give up hope."" But "that attitude may be uniquely American" because "in Western countries with government-sponsored health care, both the amount of care and access to it are limited." With Medicare projected to "run out of money in about seven years, "I suspect there will have to be some form of rationing. ò€¦ The question is whether age is the only - or even one of many - factors that should be used," said Olivia Mitchell, "an expert on insurance and risk management at Penn"s Wharton School" (McCullough, 7/6). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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