The Use Of Short Tandem Repeat Profiling To Characterize Human Bladder Cancer Cell Lines
UroToday.com - My laboratory established a series of urothelial cancer cell lines at the University of Michigan. Having worked with them for more than 2 decades, I became aware of some inconsistencies in results. This led to defining the genomic signature of the cell lines to assure that contamination was not the of these errors. We did find evidence for contamination both in our lab and in the laboratories of our collaborators. Cell line verification has recently been identified by the NIH as a component of high quality research. This manuscript describes unique signatures that can be used to identify my cell lines.
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