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FDA Approve One-Pill Version Of Plan B, Sets Over-The-Counter Access At Age 17
FDA approved Teva Pharmaceuticals" Plan B One-Step -- a single-pill version of the two-pill dose emergency contraceptive product Plan B -- and lowered the limit for over-the-counter purchase of the drug to age 17, the company announced on Monday, the AP/Yahoo! Finance reports (AP/Yahoo! Finance, 7/13). Individuals ages 16 and younger will be required to obtain prescriptions to purchase Plan B, which reduces the chance of pregnancy when taken within 72 hours of sexual intercourse (Teva Pharmaceuticals release, 7/13). Teva said the one-pill version will be available at retail pharmacies in August (AP/Yahoo! Finance, 7/13). Kelli Conlin, president of the National Institute for Reproductive Health, said, "Health care providers and women"s advocates have been eager for a one-pill emergency contraceptive for years and are happy to see it finally come to fruition" (Teva Pharmaceuticals release, 7/13).The expanded access to the medication comes several months after a federal court lifted restrictions put in place under former President George W. Bush that limited OTC sales to women ages 18 and older (AP/Yahoo! Finance, 7/13).
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Polymorphism In Endostatin, An Angiogenesis Inhibitor, And Prostate Cancer Risk And Survival: A Prospective Study
UroToday.com - Angiogenesis is the process of new blood vessel formation in tumors, facilitating their growth. Endostatin is a cleavage product of collagen and is a potent inhibitor of endothelial cell proliferation and migration. Endostatin causes apoptosis in endothelial and tumor cells. Prostate cancer expresses angiogenic factors.
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What Is Pulmonary Embolism? What Causes Pulmonary Embolism?
An embolism - from the Greek çİmbolos meaning "stopper" or "plug" - is the term that describes a condition where an object called an embolus is created in one part of the body, circulates throughout the body, and then blocks blood flowing through a vessel in another part of the body. Emboli (plural of embolus) are not to be confused with thrombi (plural of thrombus), which are clots that are formed and remain in one area of the body without being carried throughout the bloodstream.
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Polymorphism In Endostatin, An Angiogenesis Inhibitor, And Prostate Cancer Risk And Survival: A Prospective Study

UroToday.com - Angiogenesis is the process of new blood vessel formation in tumors, facilitating their growth. Endostatin is a cleavage product of collagen and is a potent inhibitor of endothelial cell proliferation and migration. Endostatin causes apoptosis in endothelial and tumor cells. Prostate cancer expresses angiogenic factors. A missense mutation in the coding region for endostatin has been described, but the polymorphism affects protein conformation rather than protein expression. Cellular assays suggested that the result is impaired endostatin binding to laminin, a basement membrane protein. In an online article in the International Journal of Cancer, Dr. Lorelei Mucci and colleagues present data from the Physicians" Health Study examining the D104N endostatin polymorphism in relation to prostate cancer risk and survival. The Physicians" Health Study was a randomized trial of aspirin and beta-carotene supplementation among 22,071 physicians ages 40-84 that was initiated in 1982. A total of 14,916 participants had samples available for this nested case-control study. The analysis identified 544 incident prostate cancer cases and 678 controls for polymorphism genotyping. Among the control men, 84.2% were wildtype homozygous (DD), 14.5% were heterozygous (DN), and 1.3% were homozygous carriers of the rare allele (NN). Carriage of the polymorphic N allele was not associated with risk of total prostate cancer risk. There was no evidence that the endostatin D104N polymorphism was associated with prostate cancers diagnosed at a younger or older age. There was also no association between carriage of the N allele and development of lethal prostate cancer. Participants whose prostate cancer contained the polymorphic allele were less likely to be overweight or obese (26%) compared to men with the DD genotype (47.8%). This large study observed no overall association between the D104N endostatin polymorphism and prostate cancer risk or prognosis. Mucci LA, Stark JR, Figg WD, Schumacher F, Li H, Abe M, Hennessy K, Stampfer MJ, Gaziano JM, Ma J, Kantoff PW Int J Cancer. 2009 Mar 11. (Epub ahead of print) 10.1002/ijc.24423 Written by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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