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Senate Minority Leader McConnell Says He Will Oppose Sotomayor As Other Republicans Back Nominee
Senate Minority Leader Mitch McConnell (R-Ky.) on Friday announced that he will oppose Supreme Court nominee Sonia Sotomayor, even as increased Republican support seemed to ensure that she would be confirmed, the New York Times reports. McConnell said that he would not support Sotomayor"s nomination because her "record of written statements suggests an alarming lack of respect for the notion of equal justice, and, therefore, in my view, an insufficient willingness to abide by the judicial oath." McConnell intends to deliver the remarks to the Senate on Monday. Meanwhile, Republican Sens. Richard Lugar (Ind.), Mel Martinez (Fla.) and Olympia Snowe (Maine) said that they would support Sotomayor. The Times reports that the senators" backing of Sotomayor -- combined with her "solid Democratic support" -- shows that she should receive "strong confirmation approval" (Hulse, New York Times, 7/18). Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) and ranking member Jeff Sessions (R-Ala.) would not predict how many Republicans could vote for her confirmation. Sessions said that Republicans are seeking a committee vote on Sotomayor on July 28, one week later than the date sought by committee Democrats. During that week, Republicans hope to review her record, her answers from her confirmation hearings and other responses to questions (AP/Boston Globe, 7/20).
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Stuff Of Stink Bombs Investigated For Role In Pregnancy
Scientists at the University of Leicester are investigating how the stuff of stink bombs and flatulence could play a critical role in the human reproductive system.
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Accelr8 Launches Clinical Specimen Study With Combined Test Methods
Accelr8 Technology Corporation (NYSE Amex:AXK) announced the start of a comprehensive study that integrates its BACcel™ test methods using respiratory clinical specimens from ICU patients. Accelr8"s scientists had previously developed each of its test methods using cultured strains. Development then progressed to clinical specimens, focused on optimizing each individual step. The next stage of combining the steps begins with the new study. The study will test ICU respiratory specimens and compare results with those from standard culturing methods (the "gold standard" for testing). Study completion will constitute a major technical milestone toward commercialization.
Diagnostics

Researcher Offers Hope For Male Diabetes Sufferers - Hereditary Diabetes Insipidus

Scientists at Glasgow have made a significant discovery in the study of a rare form of diabetes which predominantly affects men. Hereditary Diabetes Insipidus is, according to experts, the most common genetic disease known in medicine. It causes serious kidney malfunction and can, if untreated, be fatal. There are an estimated to be around 9000 Heredirary DI patients in the UK. Although the genetic basis of the disease has been established for a number of years, researchers in the faculty of Biomedical and Life Sciences at Glasgow have now pin-pointed an approach to treatment that may be expected to pave the way for future drug development. The report has been published in the highly respected international journal, Proceedings of the National Association of Sciences of the USA (PNAS). Graeme Milligan, Professor of Molecular Pharmacology at the University of Glasgow, and one of the authors on the report, said their findings are of "immense significance" because current strategies used for treatment have limited effect. He explained: "The gene that is responsible for Hereditary Diabetes Insipidus is found on the X chromosome, which is why it is a predominantly male condition. Genetic defects cause the V2 vasopressin receptor found in the kidney to malfunction. "In turn this reduces the capacity of the organ to concentrate urine, which is why patients need to go to the toilet frequently and drink large volumes of water, because the receptor is not responding to Vasopressin or Antidiuretic Hormone (ADH) produced to regulate the body"s retention of water. The result of these genetic mutations in the receptor protein mean that it fails to mature, fold and function properly." "These findings are important for sufferers long term, because our studies have employed novel, early stage drugs that can activate the mutated forms of the V2 vasopressin receptor. Further improvements to these drugs will result in their use by patients." The work was also carried out with Joris Robben who now works at the University of Nijmegen, in Holland, from Glasgow. Hereditary Diabetes Insipidus is not the only genetic disease in which mutation of a receptor results in its inability to fold and function correctly, so the approach we have taken may be equally applicable to these other conditions. To view the paper abstract please see here. Nexxus Scotland


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