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Small Business Owners Deliver Mixed Messages To Capitol Hill
As more specific legislative language emerges on health care, "small business organizations are encouraging members to make their views known through e-mails, letters, phone calls and personal visits" to members of Congress, but "the message is a decidedly mixed one," Kaiser Health News reports. "Small business, a powerful constituency in every congressional district, no longer speaks with one voice on health care. Many of the bigger and more powerful groups that represent small businesses, including the National Federation of Independent Business (NFIB) and the U.S. Chamber of Commerce, have long been allied with Republicans and are lobbying hard against the public option and the employer mandate." But newer, less conservative groups, including the Main Street Alliance, are advocating for those same hot button issues.
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Advocates Express Concern About Embryonic Stem Cell Research Guidelines As Comment Period Closes
Supporters of embryonic stem cell research have expressed concern about the impact on existing research efforts under the Obama administration"s draft guidelines outlining criteria for federal funding of stem cell research, the Washington Post reports. The public comment period for the guidelines ends Tuesday and has generated more than 20,000 comments addressing nearly every element of the proposal. The guidelines, which NIH issued in April, propose limiting federal funding for the research to stem cells derived from unused embryos created for fertility treatments and willingly donated by patients who have given written consent. Former President George W. Bush in August 2001 enacted restrictions limiting federal funding for the research to the 21 stem cell lines existing at the time. Although President Obama in March signed an executive order lifting Bush"s restrictions, some proponents of embryonic stem cell research have suggested that Obama"s plan could actually jeopardize many existing research efforts. The Obama administration is expected to issue its final version of the guidelines by July 7, the Post reports.After Bush restricted federal funding to the embryonic stem cell lines already in existence, many researchers turned to private donors and state governments for the financial support to create hundreds of new lines. Although supporters of the research initially were pleased that the Obama administration"s guidelines would allow federal funding for research on these new existing lines, some are now concerned that certain stipulations in the new guidelines could actually disqualify these research efforts from receiving federal funding. For example, NIH"s proposal requires that couples who wish to donate unused embryos for research sign a consent form indicating that they were fully informed of their alternatives. Although many fertility clinics provide information for couples about their other options, few clinics note these details in written consent forms, according to the Post. Therefore, existing stem cell lines derived from embryos donated by couples who did not sign the required consent forms could be ineligible under NIH"s draft proposal, the Post reports. In addition, many stem cell research supporters also expressed disappointment that only unused embryos created for fertility treatments would be eligible for federal funding.George Daley of the Harvard Stem Cell Institute said that the Obama administration"s guidelines "take 2009 standards and attempt to apply them retroactively, which isn"t really a standard that would allow most of the pre-existing lines to be acceptable for NIH funding." Lawrence Goldstein, director of the University of California-San Diego"s stem cell program, said, "It"s not that past practices were shoddy. But they don"t necessarily meet every letter of the new guidelines moving forward." Goldstein added that researchers would "have to throw everything out and start all over again" under the new proposed guidelines. Amy Comstock Rick, CEO of the Coalition for the Advancement of Medical Research, said that her group is "very concerned" about the funding prospects for existing research efforts, adding that if NIH officials do not modify the guidelines, "very little current research would be eligible" to receive federal funds. However, Raynard Kington, acting NIH director, said the agency is aware of the concerns and "will take them into consideration." He added that "it"s unambiguous that the intent of the president was to expand opportunities and research in this area," as long as such research is "scientifically worthy" and "ethically responsible" (Stein, Washington Post, 5/25).
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Secretary Sebelius Praises National Conference Of State Legislatures Vote In Favor Of Health Insurance Reform
HHS Secretary Kathleen Sebelius congratulated the National Conference of State Legislatures (NCSL) after the conference approved an amendment in favor of health insurance reform. The amendment was approved by a vote of 38-11. According to NCSL rules, amendments must receive 75 percent of the vote in order to pass.
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Thermo Scientific DNA Polymerases And Master Mixes Improve Yield And Specificity In PCR Amplifications

Thermo Fisher Scientific Inc., the world leader in serving science, announced it offers a premium collection of Thermo Scientific Taq DNA polymerases that are licensed and optimised for use in PCR processes. ThermoPrime Taq DNA Polymerase and Thermo-Start® Taq DNA Polymerase are designed to provide excellent amplification specificity and improved product yield. In addition, the high purity of these enzymes ensures their consistent and reliable performance. ThermoPrime Taq DNA Polymerase exhibits enhanced thermal stability at DNA denaturation temperatures, ensuring optimal enzyme activity throughout the thermal cycling process and maximum product yield. Suitable for the amplification of templates up to 4kb in length, this high performance enzyme is ideal for both standard and long PCR applications. Thermo-Start DNA Polymerase is a chemically modified version of ThermoPrime Taq DNA Polymerase, developed to ensure high specificity in hot-start PCR applications. Unlike other hot-start DNA polymerases, the modification in Thermo-Start DNA Polymerase is extremely stable (requiring heating at 95ÂôC for 15 minutes for activation) and results in sustained activity of the enzyme over an extended number of cycles with high denaturation temperatures. This eliminates non-specific amplification and increases product yield. These ultra pure enzymes are also available in convenient master mix formats for quick, easy and reproducible setup of reagents - ideal for high throughput applications. Dr. Justin Pachebat of the Genome Mapping and Sequencing facility at the University of Cambridge, UK, said, "We perform high throughput PCR typing for physical genome mapping, setting up 5,000 reactions per run in 384-well plates. In a direct comparison with our previous PCR mix, using the same reaction conditions, we found the Thermo-Start PCR Master Mix to be highly suitable for high-throughput/robotic PCR applications, giving us remarkably better results." The ThermoPrime and Thermo-Start PCR Master Mixes are also available with ReddyMix™, a unique PCR Buffer that is specially formulated with a red tracker dye to allow direct loading of the PCR product onto gel. For a full product listing and further information visit http://www.thermo.com/gen. Thermo Fisher Scientific


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