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Growing Evidence Of Marijuana Smoke's Potential Dangers
In a finding that challenges the increasingly popular belief that smoking marijuana is less harmful to health than smoking tobacco, researchers in Canada are reporting that smoking marijuana, like smoking tobacco, has toxic effects on cells. Their study is scheduled for the Aug. 17 issue of ACS" Chemical Research in Toxicology, a monthly journal.
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Latest Updates From The Alzheimer's Disease Neuroimaging Initiative (ADNI)
Alzheimer imaging aficionados thronged to back-to-back meetings held recently in Seattle for a preview of the latest data from the Alzheimer"s Disease Neuroimaging Initiative (ADNI). Launched in the fall of 2004 and set to conclude next year, the $64-million ADNI is comparing imaging methods and fluid biomarkers in the same set of people to determine which measures can best predict and track Alzheimer-disease clinical changes over time. The project is approaching the homestretch of data collection. By the fall of 2010, ADNI scientists will have collected three years of longitudinal data from more than 800 participants (about 200 normal, 400 with mild cognitive impairment (MCI), and 200 with Alzheimer disease) at 59 U.S. and Canadian sites. The Seattle meetings featured preliminary analysis of the one-year data.
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Patients Say Costs Determining Factor In Their Treatment Decisions
Seventy-three percent of insured patients receiving assistance from Patient Access Network (PAN) Foundation reported that health care costs are influencing their medication and treatment decisions more this year than last. Nearly half of these said that cost is having a "very big" or "big" impact on whether they seek treatment or fill prescriptions.
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Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity

Why the immune system of a pregnant woman does not attack her developing fetus is one of most remarkable features of pregnancy, and several underlying mechanisms have been described. However, Adrian Erlebacher and colleagues, at the New York University School of Medicine, New York, have now identified a new mechanism to explain why the mouse maternal immune system does not attack the fetuses. Once an embryo implants into the wall of the uterus, a cellular structure known as the decidua forms around the embryo and placenta. In the study, the formation of the decidua was found to prevent immune sentinel cells known as DCs from leaving the maternal/fetal interface and traveling to the local lymph nodes to activate an immune response toward the fetus. The authors therefore suggest that impaired formation or function of the human decidua might allow DCs to leave the decidua to initiate an aggressive immune response toward the fetus, something that might contribute to poor pregnancy outcomes. In an accompanying commentary, Bali Pulendran, at Emory Vaccine Center at Yerkes National Primate Research Center, Atlanta, discusses how this new research affects current thinking about avoiding immune surveillance at the maternal/fetal interface. TITLE: Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice AUTHOR CONTACT: Adrian Erlebacher New York University School of Medicine, New York, New York, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=38714 ACCOMPANYING COMMENTARY TITLE: Restraining order for dendritic cells: all quiet on the fetal front AUTHOR CONTACT: Bali Pulendran Emory Vaccine Center at Yerkes National Primate Research Center, Atlanta, Georgia, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=39946 Karen Honey Journal of Clinical Investigation


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