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Novavax Announces Selection Of A Respiratory Syncytial Virus Vaccine Candidate For Advanced Preclinical Studies
Novavax, Inc. (Nasdaq: NVAX) announced final selection of a Respiratory Syncytial Virus (RSV) vaccine candidate that will be advanced into additional preclinical studies to support an Investigational New Drug (IND) application. As previously announced, Novavax has been evaluating a number of RSV vaccine candidates, all of which have successfully induced antibody responses in mice. Novavax scientists have now engineered a new vaccine candidate which has been shown to protect mice against RSV disease and can be produced at sufficient yields to allow commercial manufacture. This new candidate is directed against a protein on the surface of the virus, the "F" or "fusion" protein, which is the protein that the virus uses to infect and fuse with cells in the respiratory tract and cause disease.
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'Death Receptors' Designed To Kill Our Cells May Make Them Stronger
It turns out that from the perspective of cell biology, Nietzsche may have been right after all: that which does not kill us does make us stronger. In a review article published in the June 2009 print issue of The FASEB Journal, scientists from the Mayo Clinic explain how cell receptors (called "death receptors") used by the body to shut down old, diseased, or otherwise unwanted cells (called "apoptosis") may also be used to make cells heartier when facing a wide range of illnesses, from liver disease to cancer.
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Nearly Half Of Older Patients Projected To Die While Waiting For Kidney Transplant
Forty-six percent of patients over age 60 currently on the waiting list for a kidney transplant will die before they receive an organ from a deceased donor, reports an upcoming study in the Clinical Journal of the American Society of Nephrology (CJASN). "Our results emphasize the particular need to consider living donation as an alternative for some older patients or alternatively, the critical importance of navigating the steps to receive a deceased donor transplant as rapidly as possible," comments Jesse D. Schold, PhD (University of Florida, Gainesville).
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What Is The Difference Between Hip Resurfacing And Total Hip Replacement?

If hip resurfacing is an option, the surgeon will simply reshape the damaged surface of the femoral ball and then cover it with a round metal cap. The limitation here is that the procedure only works for bone that is not too damaged by arthritis. Generally speaking, surface replacements are not performed on patients with serious arthritic conditions, because if the bone is not strong enough, there is a small but real risk of fracturing. Therefore the average age of resurfacing patients may be 50 years or younger. Statistically, the resurfacing operation is an option for about 7 out of a 100 patients. For the alternative procedure of a total hip replacement the surgeon will remove the entire arthritic ball. He will then prepare the top end of the thighbone to receive a metal anchor (stem). This stem will fill the bony canal for stability. Once that is fixed in place, he will simply cap it with a suitable size of ball. In both hip resurfacing and total hip replacement procedures, the surgeon will reshape the damaged surface of the bone and install a metal cup. With resurfacing the second limitation is that only a certain type of metal bearings can be used, which may wear and release debris and metal ions. This creates a 3rd limitation for resurfacing, in that some surgeons will exclude female patients of childbearing age due to unknown effects of metal ions on the pregnancy. With total hip replacement, the removal of the diseased ball gives the surgeon many more options in material choices, for example polyethylene, cobalt-chrome alloy and ceramics. There are also additional choices in various ball diameters and cup designs that resurfacing does not have. Thus total hip replacement is a far more common procedure than hip resurfacing and has a much longer history worldwide. Your doctor should explain to you which hip replacement is best for you and why. About Author Jeremy Reither manages the online outreach effort for BoneSmart®, which is dedicated to raising global awareness about knee replacement and hip replacement options for consumers. He specializes in raising consumer awareness through the use of new media and internet technologies. Bonesmart.org


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