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Celgene Announces Positive Top Line Data From Randomized Controlled Phase II Study Of Apremilast In Psoriatic Arthritis
Celgene Corporation (NASDAQ: CELG) announced the preliminary results of a phase II, multi-center, randomized, double-blind, placebo-controlled, three-arm study of apremilast - a novel, orally available small molecule that exhibits anti- inflammatory activities through the suppression of multiple pro-inflammatory mediators and cytokines - in adult patients with psoriatic arthritis (CC-10004-PSA-001). The study met its primary objective of assessment of ACR20 at 12 weeks. ACR20 is defined as the percentage of patients achieving a 20% or better improvement according to the American College of Rheumatology (ACR) criteria. ACR20 is the primary assessment utilized by the U.S. Food and Drug Administration for assessment of efficacy in psoriatic arthritis, as well as rheumatoid arthritis.
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Cannabis Science Receives FDA Industry Guidelines For Mapping Out Its Initial Drugs Offerings For FDA Submission And Testing
Cannabis Science Inc. (OTCBB: CBIS), an emerging pharmaceutical cannabis company, is pleased to report that the FDA has provided the Company with documentation to assist the Company to review and plan its initial applications to get its first drug into formal testing.
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Subsidies To Cover Uninsured Critical To Health Overhaul
Covering the uninsured - a leading principle of health care reform - depends on the critical issue of who gets subsidies to pay for health insurance coverage and when.
Oncology

Highlights Of Pain Research

and four hours post-operatively. Total opiate consumption was also recorded. The result: There was significantly less post-operative pain in group A (Bupivacaine intra-articular and periportal skin infiltration), compared with group C (no infiltration) immediate postoperatively and one hour post-operatively, and compared with group B (Bupivacaine periportal skin infiltration) two hours and four hours post-operatively. There were no significant differences in visual analogue scores between groups B and C at any time-points. Group A used significantly less opiates post-operatively compared with group B or C but there was no significant difference in opiate use between groups B and C. Dr Bunn: "Intra-articular local anaesthetic significantly reduces post-operative pain, but at what cost to the chondral surface? Local skin infiltration of the arthroscopy portals does not significantly alter pain levels or opiate requirements. Avoidance of "intra-articular" local anaesthetic raises opiate requirements. We require improved alternative analgesic regimes." Abstracts: EFORT 2009 Abstract: Sharma A et al, Errors in prescription of regular medication in emergency surgical admissions-clinical audit. EFORT 2009 Abstract: Torrens C et al, Change in patient self-evaluation of pain, function and satisfaction before and after clinical visit. EFORT 2009 Abstract: Miquel J et al, Influence of pain and mobility in quality of life perception in shoulder disorders. EFORT 2009 Abstract: Huber J et al, Assesment of pain during activity, at rest and at night - do we have to assess all three different pains? EFORT 2009 Abstract: Bunn J et al, The efficacy of post-operative regimes following hip arthroscopy. EFORT

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