Public Health
Cases of type 1 diabetes in children under five years across Europe will double by 2020 (from 2005 levels) if present trends continue. Numbers in children older than five will also increase substantially. The findings are discussed in an Article published Online First and in an upcoming edition of The Lancet, written by Dr Chris Patterson, Queen"s University, Belfast, UK, and Prof Gyula Soltç©sz, Pç©cs University, Pç©cs, Hungary, and colleagues.
The Scottish Government is launching Better Diabetes Care - a consultation to improve diabetes care over the next three years - Diabetes UK Scotland is encouraging everyone to take part.
The criteria used to assess blood alcohol concentrations (BACs) and binge drinking behaviors in children and adolescents should be based on pediatric rather than adult physiology, according to a new University of Pittsburgh study in the June issue of Pediatrics.
Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced that the European Medicines Agency has granted Orphan Drug Designation to AMT"s gene therapy product AMT-021 for the treatment of acute intermittent porphyria (AIP).
Supermarket shoppers may be encouraged to buy sugar-filled, calorie-rich drinks by discounts and promotions, according to New Zealand research.
Abortion-rights groups on Wednesday offered their support for Supreme Court nominee Judge Sonia Sotomayor but said that they were eager to learn more about her views on abortion rights, an issue on which she has made few major rulings in her time as a judge, the New York Times reports. According to the Times, groups on both sides of the abortion-rights debate tend to believe that Sotomayor would uphold Roe v. Wade because she was nominated by President Obama, who supports abortion rights. However, when asked on Tuesday if Obama questioned Sotomayor about her views on abortion rights before the nomination, White House spokesperson Robert Gibbs said that the president "did not ask that specifically." In addition, none of her rulings has directly dealt with the underlying issues of constitutional privacy that are the foundation for the Roe decision, according to the Times. The abortion-related cases Sotomayor has handled in the past have "turned on other legal issues," rather than privacy, and they have resulted in rulings in favor of abortion-right opponents, the Times reports. For example, in 2002, she wrote an opinion upholding the Bush administration"s "global gag rule" policy banning federal funding of international groups that offer abortion information or services. "The Supreme Court has made clear that the government is free to favor the antiabortion position over the pro-choice position and can do so with public funds," Sotomayor wrote in the opinion. In 2004, she said that antiabortion-rights protesters were permitted to sue police who they claimed used excessive force in stopping a demonstration at a clinic. Sotomayor also has ruled on several immigration cases related to people fighting deportation orders to China over its family planning policies, the Times reports. Because of the limited information on Sotomayor"s abortion-rights views, advocates have stressed that senators ask questions about her views during her confirmation hearing. NARAL Pro-Choice America President Nancy Keenan in a letter to supporters urged them to press senators to ask Sotomayor about privacy rights. Keenan wrote, "Discussion about [Roe] will -- and must -- be part of this nomination process. As you know, choice hangs in the balance on the Supreme Court as the last two major choice-related cases were decided by a 5-to-4 margin" (Savage, New York Times, 5/28). Nancy Northup, president of the Center for Reproductive Rights, said that she would be surprised if an Obama nominee did not support abortion rights but added that "other presidents have been surprised before" when their nominees" views did not align with their assumptions. Northup said that "no one has been able to give us an assurance" of Sotomayor"s views on abortion rights, adding that she would be "very concerned if the question is not asked and answered during the Senate hearings." Feminist Majority Foundation President Eleanor Smeal said, "What we know about [Sotomayor] we like, but I don"t know that answer on abortion rights" (Savage/Nicholas, Los Angeles Times, 5/28). The New York Times reports that more about Sotomayor"s views on abortion rights could come to light if a past writing on the subject surfaces, as was the case during Justice Samuel Alito"s confirmation process. Steven Waldman, editor in chief of beliefnet.com, said, "Everyone is just assuming that because Obama appointed her, she must be a die-hard pro-choice activist, but it"s really quite amazing how little we know about her views on abortion" (Savage, New York Times, 5/28). Thomas Goldstein, a leading appellate attorney and founder of scotusblog.com, said that the "fact that she hasn"t gone off on these sorts of questions" on contentious topics like abortion rights and gay marriage, "I think shows that honestly she"s not a dyed in the wool liberal." He added that there are issues on which Sotomayor could prove to be more conservative than retiring Justice David Souter (Lerer, Politico, 5/27).According to the Washington Post, many antiabortion-rights supporters are critic
At least six states have considered eliminating or reducing financial assistance for those enrolled in the Medicare prescription drug benefit program who are affected by the "doughnut hole," or gap in coverage, the AP/Boston Herald reports. According to the AP/Herald, the governors of Rhode Island and Vermont and lawmakers in South Carolina have proposed plans to eliminate such financial assistance programs, while Massachusetts has reduced funding for its program. Meanwhile, proposals in New York and Connecticut to limit financial help have been dismissed.Beneficiaries enrolled in the drug benefit have coverage until total spending reaches $2,700 and then must pay out-of-pocket for their medications until the total spending reaches $4,350, after coverage. At least 16 states provide financial help to beneficiaries who have reached the coverage gap (AP/Boston Herald, 5/27).
Thailand has set a goal of reducing by half the number of new HIV cases in the country by 2011, Prime Minister Abhisit Vejjajiva said on Wednesday, TNA/MCOT English News reports. Abhisit was speaking at the opening ceremony of the three-day 12th National Seminar on AIDS, which more than 2,500 HIV-positive people, students, and participants from Thai agencies, private sector groups and international organizations are expected to attend. The seminar will focus on the government"s plan to reduce new cases by 2011 and the national HIV/AIDS action plan."The government"s plan, if successful, will be the result of cooperation from all sides," Abhisit said. He added that statistics indicate that one in four new HIV infections occur among men who have sex with men. In addition, new cases among married women in the country have increased by 30% to 40%, according to Abhisit. He said that he will be involved in a campaign to promote fidelity among married couples in the country (TNA/MCOT English News, 5/27).
The fishing industry and some cultural practices in communities living around Africa"s Lake Victoria are contributing to the spread of HIV/AIDS and other sexually transmitted infections in the area, according to a panel of experts at a recent meeting in Kisumu, Kenya, The Citizen reports. According to the panel, cultural practices such as widow inheritance, commercial sex work for fish and the long-distance trucking industry have led to the spread of HIV/AIDS. HIV/AIDS prevalence among women and people who live along the beaches of the lake is particularly high, the meeting participants noted.The four-day meeting was held by the Lake Victoria Basin Commission and involved members of the East African Community and other officials. Meeting delegates were taken to cross-border control posts along the Kenya-Uganda border to interact with people living with HIV/AIDS, commercial sex workers, long-distance truck drivers and district government officials. Doreen Othero, HIV/AIDS technical specialist at the LVBC Secretariat, said that the group "managed to bring together organizations working in HIV/AIDS along transport corridors to share information, improve coordination and build synergy among the various programs so as to have maximum impact on the corridors" most at risk populations."Jean Claude Nsengiyumva, EAC deputy secretary general in charge of productive and social sectors, said that the fight against HIV/AIDS will be successful through a coordinated and collaborative effort among all stakeholders. He said that EAC has introduced a four-year Regional Multisectorial HIV/AIDS Strategic Plan, ending in 2012, that aims to address HIV/AIDS in the region. The region also is undergoing efforts to create more collaboration between regional, international and multisectorial organizations that have projects for HIV/AIDS education, care, treatment and testing. Othero said there are more than four million HIV-positive people and more than 3.5 million orphans and vulnerable children in EAC partner states (The Citizen, 5/27).
Low vitamin D levels in blacks could contribute to health gaps between white and black U.S. residents, Michael Holick, a professor at Boston University and a vitamin D researcher, said recently, the GNS/Chicago Sun-Times reports. According to Holick, blacks have lower levels of vitamin D than whites in part because the higher amount of pigment in their skin makes it harder for their body to absorb the nutrient, which is produced in response to sun exposure. Although scientists are debating optimum vitamin D levels, some scientists have said that vitamin D can reduce the risk of cancer, diabetes, heart disease and other illnesses. Holick added that some scientists believe blacks are more likely to have prostate cancer, breast cancer and colon cancer and have more aggressive forms of the cancer because they have lower levels of vitamin D. John Flack, principal investigator at the Center for Urban and African American Health at Wayne State University, said lower vitamin D levels among blacks is "potentially a very important explanation for some of the differences, from hypertension to cancer to heart failure," adding, "The actual proof is not there, but it"s plausible." Flack added that many factors -- including decreased access to health care and differences in income and education -- contribute to the overall poorer health among blacks. The Institute of Medicine next year is expected to release new guidelines on recommended daily intake for vitamin D. "All Americans, but particularly people with darker skin, should pay attention" to the new guidelines, according to Adit Ginde, a researcher at the University of Colorado Denver School of Medicine who led a recent study that found vitamin D levels are decreasing in all racial groups and are particularly low in blacks (Painter, GNS/Chicago Sun-Times, 5/28).
Sabrina Daneshvar, Ph.D., BCBA-D of Southern California-based Autism Spectrum Therapies (AST), participated in a panel discussion on generalization at the Association for Behavior Analysis International (ABAI) Conference held in Phoenix, Arizona, May 22-26, 2009. The discussion addressed strategies for increasing generalization and focused on training approaches that increase success.
ProTrials Research, Inc.TM, a leader in the clinical research organization industry, announced Medivation, Inc. (NASDAQ:MDVN) has chosen the company to conduct separate international Phase III clinical trials for two novel treatments. ProTrials will test MDV3100 for treating prostate cancer and the investigational drug Dimebon TM as a treatment for Huntington"s disease. Due to the complex nature of these Phase III trials, Medivation again selected ProTrials as its contract research organization partner because of ProTrials" successful past performance with the company"s Phase I, II and III trials.
To help customers have a safe and fun summer in the sun, Rite Aid and The Skin Cancer Foundation are partnering to raise awareness and offer free information on the importance of smart skin care practices. A free skin care guide aimed to encourage customers to protect their skin this summer will be available at nearly 4,900 Rite Aid stores nationwide and online at http://www.riteaid.com starting May 31.
Clinipace, a digital clinical research organization, announced that Inspire Pharmaceuticals, Inc. has selected the company to manage and deploy two phase II studies for the ophthalmic prescription medicine, AzaSite®.
Oculus Innovative Sciences, Inc. (Nasdaq: OCLS), a healthcare company that develops, manufactures and markets a family of products based upon the Microcyn® Technology platform, today announced that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its Microcyn® Skin and Wound Gel as both a prescription and over-the-counter formulation. The Rx product, under the supervision of a health care professional, is intended for management of exuding wounds such as leg ulcers, pressure ulcers, diabetic ulcers and for the management of mechanically or surgically debrided wounds. This is the first hydrogel product based upon the Microcyn Technology platform and is reimbursable by both Medicare and Medicaid.
Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the initiation of a Phase 3 registration program for VX-770, an investigational Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) potentiator that targets the defective CFTR protein that causes cystic fibrosis (CF). The VX-770 registration program will consist of three clinical trials, including a primary 48-week Phase 3 trial that is currently open to enrollment of patients aged 12 years and older who carry the G551D mutation on at least one allele. Two additional trials will evaluate VX-770 in patients aged 6 to 11 years with the G551D mutation on at least one allele and in patients homozygous for the F508del mutation, respectively.
Healthcare Locums (HCL), the UK"s largest specialist health and social care agency, says it is seeing rocketing demand for locum and permanent placement doctors from Trusts struggling to prepare for the European Working Time Directive, which limits the number of hours trainee doctors can work to 48 per week.
Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.
The atherosclerosis vaccine development program by
Once symptoms start, there"s only a tiny window of time for stroke victims to get life-saving treatment. Now, research from the Stanford University School of Medicine has cracked that window open a bit wider.
A new study appearing in Congestive Heart Failure has found that the presence of anemia in patients with chronic heart failure is associated with a significantly increased risk of death. The findings also show that anemia is associated with a poorer degree of left ventricular function and a lower left ventricular ejection fraction, an objective measure of cardiac function.
President Barack Obama and Energy Secretary Steve Chu are consistent in their message that when it comes to transportation fuels, carbon-neutral biofuels as an alternative to gasoline are coming. While the focus of a shift from gasoline to biofuels has been on global warming, such a shift could also impact human health. A grant from the Energy Biosciences Institute (EBI) has produced a novel and comprehensive "Life Cycle Impact Assessment" to measure the benefits on human health that might result from a switch to biofuels. Although there are a number of uncertainties that must be addressed for a more accurate picture, these early results show that a biofuel eliminating even 10-percent of current gasoline pollutant emissions would have a substantial impact on human health in this country, especially in urban areas.
Researchers at the University of California, San Francisco, and collaborators at Harvard Medical School have linked a specialized protein in human muscles to the process that clears glucose out of the bloodstream, shedding light on what goes wrong in type 2 diabetes on a cellular level.
An analysis of previous studies indicates that among patients with peripheral artery disease, aspirin use is associated with a statistically nonsignificant decrease in the risk of a group of combined cardiovascular events (nonfatal heart attack, nonfatal stroke, and cardiovascular death), but is associated with a significant reduction in the risk of one of these events, nonfatal stroke, although the findings may be limited by the lack of a large study population, according to an article in the May 13 issue of JAMA.
Agios Pharmaceuticals today announced that Stand Up To Cancer (SU2C), a charitable initiative for new cancer treatments, has selected the Cancer Metabolism "dream team" led by Agios founder Dr. Craig Thompson and including Agios advisors Drs. Chi Dang and Joshua Rabinowitz. Cancer Metabolism is one of only five research areas chosen to share in $73.6 million in translational research funding, based on a rigorous selection process by independent scientific advisors assembled by SU2C"s scientific partner, the American Association for Cancer Research (AACR). Cancer metabolism is a new and exciting field of biology that represents a breakthrough understanding of how cancer cells become addicted to using more nutrients than normal cells to ensure their survival and growth. This new understanding of a fundamental mechanism of cancer represents a powerful Achilles" heel to target this deadly disease.
The New Zealand Medical Association (NZMA) welcomed today"s Budget which reaffirms the Government"s commitment to solving our long term health workforce problems.
Women over age 30 who regularly exercise decrease their chances of breast cancer, according to a study presented today at the American College of Sports Medicine"s 56th Annual Meeting in Seattle.
A technique that "silences," or turns off, genes shows promise as a potential new treatment for liver fibrosis - the disease that leads to cirrhosis - scientists in Tennessee are reporting. Their study is scheduled for the June 1 issue of ACS" Molecular Pharmaceutics, a bi-monthly journal. Cirrhosis is the 12th leading cause of death in the United States.
The popular belief that healthy eating starts at home and that parents" dietary choices help children establish their nutritional beliefs and behaviors may need rethinking, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health. An examination of dietary intakes and patterns among U.S. families found that the resemblance between children"s and their parents" eating habits is weak. The results are published in the May 25, 2009, issue of Social Science and Medicine.
The SNM Clinical Trials Network, an initiative designed to address the need for streamlined drug discovery through the integration of imaging biomarkers into multi-center clinical trials, recently added Genentech, Inc. as a supporter.
CuraGen Corporation (Nasdaq: CRGN) announced plans for three data presentations from its ongoing clinical trials of CR011-vcMMAE, an antibody-drug conjugate that targets GPNMB, in patients with advanced breast cancer and melanoma at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida.
Researchers at the University of Southern California (USC) and USC Norris Comprehensive Cancer Center will present breakthrough research in a number of researchstudy areas at the 2009 American Society of Clinical Oncology (ASCO) annual meeting in Orlando, Florida.
The University of California, San Francisco (UCSF) and the Multiple Myeloma Research Foundation (MMRF) have established the Stephen and Nancy Grand Multiple Myeloma Translational Initiative, a research collaboration dedicated to translating basic science discoveries into new candidate drugs for testing in clinical trials.
Today, acute heart failure represents the most common reason for hospitalisation in the over-65 population. Although hospital care improves symptoms in the first 24 hours after admission in around 50% of these patients, acute heart failure events still remain associated with a more than 50% mortality and rehospitalisation rate at 6-12 months. "Indeed," says Professor Marco Metra from the Cardiology Department of the University of Brescia, Italy, "it is the very rapid onset of symptoms and the need for urgent therapy which characterise the condition."1,2
Researchers from the University of Pittsburgh Cancer Institute (UPCI) have identified eight genes that help predict a melanoma patient"s response to treatment. The new findings are being presented at the 45th annual meeting of the American Society of Clinical Oncology (ASCO), May 29 to June 2, in Orlando, Fla.
The New York Times, Washington Post and Washington Times recently published opinion pieces on President Obama"s nomination of Judge Sonia Sotomayor to the Supreme Court. Summaries appear below.~ David Brooks, New York Times: "Supreme Court justices, like all of us, are emotional intuitionists" because "they begin their decision-making processes with certain models in their heads," Times columnist Brooks writes, adding that "[t]hese are models of how the world works and should work, which have been idiosyncratically ingrained by genes, culture, education, parents and events," and which "shape the way judges perceive the world." Therefore, the "crucial question in evaluating a potential Supreme Court justice ... is not whether she relies on empathy or emotion, but how she does so," according to Brooks. He writes that Sotomayor "will be a good justice if she can empathize with the many types of people and actions involved in a case, but a bad justice if she can only empathize with one type, one ethnic group or one social class." He concludes, "It"s not whether judges rely on emotion and empathy, it"s how they educate their sentiments within the discipline of manners and morals, tradition and practice" (Brooks, New York Times, 5/29).~ Michael Gerson, Washington Post: By opposing Sotomayor"s confirmation, Republicans could be entering "a trap" by "further alienating Hispanic voters the GOP has recently driven away in droves," which might "confirm an image of Republicans as the party of the male and pale," columnist Gerson writes in a Post opinion piece. He continues, "Barring unforeseen ethical revelations, opposition to Sotomayor seems both politically risky and ultimately futile." However, "Republicans must still enter the trap -- with open eyes and no expectation of gain -- not to defeat a nominee but to maintain a principle" that the court "should be a place where all are judged impartially, as individuals," Gerson writes. He continues that the "Obama/Sotomayor doctrine of empathy challenges this long-established belief," and this "is not a minor matter." According to Gerson, "Concerns about the doctrine of empathy will not defeat Sotomayor -- and perhaps they should not defeat her." However, the "problems raised by selective empathy require a substantive (not harsh or personal) national debate -- and this requires Republicans to carefully, warily, enter Obama"s trap" (Gerson, Washington Post, 5/29).~ Michael Kinsley, Washington Post: "What conservative Republicans don"t like about the Supreme Court can be summarized as three, or maybe four, A"s: abortion, affirmative action and activism," columnist Kinsley writes in a Post opinion piece. He adds that "[r]ecent Republican platforms have pledged to appoint judges who not only will overturn Roe [v. Wade] but will make clear that fetuses have the same rights as people under the 14th Amendment"s guarantee of "equal protection of the laws."" Kinsley continues that supporters of Roe "clearly represent the "activist" side," while opponents of the decision "are right that Roe represents the highest tide of Warren Court activism." However, this "doesn"t mean the critics of Roe are right on the merits;" rather, it means that ""activism" is a near-worthless concept, and comparative activism is nonsense," Kinsley writes. He continues, "Although I am pro-choice, Roe makes me unhappy because it was poorly reasoned, not because it "went further" than other decisions." According to Kinsley, "many opponents of Roe would not be satisfied with merely seeing it overturned and the issue returned to the states," and, in fact, the GOP platform "effectively calls for a litmus test for judges: Will they rule abortion illegal in all 50 states no matter what the people want?" He continues, "Now that would be judicial activism with a vengeance" (Kinsley, Washington Post, 5/29).~ Eugene Robinson, Washington Post: The fact that Sotomayor "is a proud and accomplished Latina" apparently "drives some prominent Republicans into a s
Driving Miranda, a protein in fruit flies crucial to switch a stem cell"s fate, is not as complex as biologists thought, according to University of Oregon biochemists. They"ve found that one enzyme (aPKC) stands alone and acts as a traffic cop that directs which roads daughter cells will take.
The following highlights efforts that seek to reduce racial and ethnic health disparities.
Scottsdale Healthcare, through its strategic alliance with the Translational Genomics Research Institute (TGen), is one of three clinical research sites in the United States that will participate in a three-year investigation into new approaches to treating pancreatic cancer, the fourth leading cause of cancer death in the U.S.
Minutes after receiving a single, powerful non-invasive radiosurgery treatment, John Sisco, 64, happily walked out of the treatment room without any need for an overnight stay in the hospital, and left for home. Doctors at Somerset Medical Center, in Somerville, New Jersey, used the advanced Novalis Tx™ platform from Varian Medical Systems (NYSE: VAR) and BrainLAB to deliver the accurate, image-guided treatment designed to eradicate an abnormal tangle of blood vessels, called an artereo-venous malformation (AVM), that had grown near Sisco"s brainstem.
Patients with inflammatory arthritis completing a health-related quality of life questionnaire report levels of pain that result in their health being rated as "worse than death" by members of the general population.
The reason deadly infections like human immunodeficiency virus (HIV) and hepatitis C never go away is because these viruses disarm the body"s defense system. Researchers at the University of Alabama at Birmingham (UAB) have discovered that a key immunity protein must be present for this defense system to have a chance against chronic infection.
Researchers at the University of California, San Diego have discovered that a complex network of interactions between drugs and the proteins with which they bind can explain adverse drug effects. Their findings suggest that adverse drug effects might be minimized by using single or multiple drug therapies in order to fine-tune multiple off-target interactions.
The NPA is asking its members to utilise the new NPA IT forums website to comment on the criteria that should be used to demonstrate that EPS is operationally functional ahead of national roll-out. The NPA believes that EPS must work technically, be business and operationally functional, improve service delivery at pharmacies, and is safe for patients, before full roll-out can be contemplated. The website, http://itforums.npa.co.uk, provides an opportunity for members throughout the UK to voice their opinions on the IT programmes affecting their country or on general IT topics which affect all nations.
Poxel is a research integrated pharmaceutical Company (RIPCO),
Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic imaging, announces that it has completed patient enrollment of CaRES (Contrast Echocardiography REgistry for Safety Surveillance), the first, multicenter Phase IV observational registry that evaluates the use of ultrasound imaging agents in routine clinical practice. The 1,060 patients who were enrolled at 15 sites in the U.S. were 18 years old or older and required DEFINITY® Vial for (Perflutren Lipid Microsphere) injectable suspension-enhanced echocardiography because of a previous suboptimal, unenhanced echocardiogram.
Talecris Biotherapeutics presented results last week from two phase III studies assessing the safety, tolerability and pharmacokinetic comparability of a more concentrated formulation of Prolastin® (Alpha1-Proteinase Inhibitor [Human]) produced via a modification of the current manufacturing process that incorporates technological changes.
The Society for Clinical Ophthalmology (SCO) is now working with UK-based Consultant Ophthalmologist, Mr Som Prasad, to supplement ophthalmic surgical training with an online forum that offers videos and online discussions of surgical techniques.
Clive N. Svendsen, joint leader of the widely-respected Stem Cell and Regenerative Medicine Center at the University of Wisconsin, has been named director of the new Cedars-Sinai Regenerative Medicine Institute, effective Dec. 1, 2009.
Around one in five hospital patients who have trouble feeding themselves do not get help with meals, according to the survey released by the Care Quality Commission (CQC).
Raptor Pharmaceuticals Corp. ("Raptor" or the "Company") (OTC Bulletin Board: RPTP), announced that it has dosed the first patient in its Phase 2b clinical trial, conducted in collaboration with the University of California, San Diego ("UCSD"), to evaluate Raptor"s proprietary delayed-release cysteamine bitartrate ("DR Cysteamine") capsules in nephropathic cystinosis ("cystinosis"), a rare genetic lysosomal storage disease. Under Raptor"s open Investigational New Drug application ("IND"), UCSD is performing the Raptor-sponsored trial at its General Clinical Research Center.
UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders, some of which increase risk for several types of cancer.
Urgent care centers (UCCs) are providing an alternative to emergency room treatment. A study published in the open access journal BMC Health Services Research has shown that UCCs tend to be open well outside of office hours and offer a wider range of services than primary care offices.
The next meeting of the General Dental Council (GDC) will take place on Thursday 11 June 2009 in the Harvey Goodwin Room, Church House Conference Centre, Dean"s Yard, Westminster, London, SW1P 3NZ from 10:30am.
Time is short for scientists to respond to the call for comments on the National Institutes of Health (NIH) proposed guidelines for the use of human embryonic stem (ES) cell lines and their eligibility for federal funds. On May 26, the window to provide feedback will close, and the drafted rules leave the possibility that funding for almost all existing cell lines will disappear.
Complications following infection with the virus that causes flu (influenza virus) are one of the top ten causes of death in the United States. Although infection with influenza virus can directly cause death, many deaths following infection with influenza virus occur because the individual develops pneumonia due to secondary infection with bacteria such as Streptococcus pneumoniae. How influenza makes individuals more sensitive to pneumonia-causing secondary bacterial infections is not well understood. However, Jane Deng and colleagues, at the University of California, Los Angeles, have now determined, through studies in mice, one mechanism by which influenza might sensitize individuals to secondary bacterial pneumonia.
Tiny fluctuations in a fetus"s heartbeat can indicate distress, but currently there is no way to detect such subtle variations except during labor, when it could be too late to prevent serious or even fatal complications.
The editors of Disability & Rehabilitation and its sister publication, Disability & Rehabilitation: Assistive Technology have announced an annual award which will be given for the best review paper published in either of the two journals. Commencing in 2009, the Informa Best Review Paper Award will recognise valuable, high-impact research in the fields of disability, rehabilitation and assistive technology.
Oligophrenin-1, a Rho-GTPase-activating protein, stabilizes postsynaptic AMPA receptors
Testing people for heart disease might be just a finger prick away thanks to a new credit card-sized device created by a team of researchers from Harvard and Northeastern universities in Boston. In a research report published online in The FASEB Journal, they describe how this device can measure and collect a type of cells needed to build vascular tissue, called endothelial progenitor cells, using only 200 microliters of blood. The development is also significant because it allows scientists to collect these cells much more easily than current techniques allow, bringing laboratory-created tissue for vascular bypass surgeries another step closer to reality.
It turns out that from the perspective of cell biology, Nietzsche may have been right after all: that which does not kill us does make us stronger. In a review article published in the June 2009 print issue of The FASEB Journal, scientists from the Mayo Clinic explain how cell receptors (called "death receptors") used by the body to shut down old, diseased, or otherwise unwanted cells (called "apoptosis") may also be used to make cells heartier when facing a wide range of illnesses, from liver disease to cancer.
Causal inference is challenging in all non-experimental studies because of the possibility of hidden bias. Hidden bias may exist as a result of failure to control for unobservable factors, such as doctors" practice/prescription patterns.
In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought. The findings, published today in the journal Nature Medicine, open up a new field for developing treatments.
ZIOPHARM Oncology, Inc. (Nasdaq: ZIOP) announced today that it presented positive data from both a Phase Ib clinical trial and preclinical dosing studies of orally administered indibulin (ZybulinTM or ZIO-301), the Company"s novel tubulin binding agent, at the 45th Annual American Society of Clinical Oncology (ASCO) meeting held in Orlando, FL, May 29th to June 2nd.
A new multi-center study, conducted at The Feinstein Institute for Medical Research in collaboration with five other centers throughout the country, tested the commonly prescribed antidepressant citalopram and found that it was no more effective than placebo in altering obsessive features of the condition - the spinning, rocking and repetitive behavior.
Depomed, Inc. (NASDAQ:DEPO) announced that it has completed enrollment of the Phase 3 clinical trial of DM-1796 for the treatment of post-herpetic neuralgia.
Infants" sleep patterns and their parents" influence on it are the focus of the SIESTA II project, supported by a five-year, $2.67 million grant from the National Institute of Child Health and Human Development to Douglas M. Teti, professor of human development and psychology, Penn State.
After drug dealing, trafficking of humans is tied with arms dealing as the second largest criminal industry in the world, and it is the fastest growing, according to the U.S. Department of Health and Human Services (HHS). Recently, HHS awarded more than $2 million in grants to state and local organizations, including the University of Missouri, to identify and help victims of human trafficking.
The National Institute of Mental Health has awarded Group Health a $1 million stimulus grant to research more effective treatment for depression. The award is part of the federal stimulus funds from ARRA, the American Recovery and Reinvestment Act of 2009.
Nigeria Releases 57M Polio Vaccines, Aims To Increase Vaccine Coverage
Plexxikon Inc. today announced preliminary data from a Phase 1 clinical study investigating PLX4032 (R7204). PLX4032 is a novel, oral and highly selective drug that targets the BRAFV600E cancer-causing mutation that occurs in most melanomas and about eight percent of all solid tumors. In patients whose cancer harbors this mutation and who were treated with therapeutic doses of PLX4032, tumor shrinkage and extended progression-free survival have been observed. Currently, two extension studies are being conducted in mutation-positive melanoma and colorectal cancer patients. Following the initial positive findings announced today, larger clinical trials to support a registration program for product approval are targeted to start later in 2009. Plexxikon and Roche are co-developing PLX4032 under their 2006 license and collaboration agreement.
Several of the country"s largest liberal groups said they were prepared to spend $82 million to promote President Obama"s health care reform agenda, the Boston Globe reports. "Joining the effort are two major labor organizations, the AFL-CIO and Change to Win; Health Care for America Now, a coalition of healthcare providers, consumer groups, and activists; MoveOn.org, the massive online activist organization; and other groups that claim a total of 30 million members."
Two studies from AstraZeneca (NYSE: AZN) show that symptomatic gastroesophageal reflux disease (GERD) patients treated with NEXIUM(R) (esomeprazole magnesium) 20 mg daily experienced greater relief from nighttime heartburn and GERD-related sleep disturbances compared with patients taking placebo over four weeks(1). NEXIUM 20 mg is indicated for the treatment of heartburn and other symptoms associated with GERD. NEXIUM, in a class of drugs called proton pump inhibitors (PPIs), demonstrated efficacy in relieving moderate-to-severe nighttime heartburn and GERD-related sleep disturbances in two randomized, placebo-controlled trials(2). These findings were presented in three separate abstracts at Digestive Disease Week 2009 in Chicago.
Innovia LLC, a privately held biomaterials-based medical device company, announced that it has received 510(k) clearance from the U.S. Food and Drug Administration to market the InnoPort(TM) to facilitate single port access laparoscopy.
MedSolutions, a leading provider of medical cost management services, will highlight its groundbreaking solution - Premerus(SM) Diagnostic Accuracy - during America"s Health Insurance Plans (AHIP) Institute 2009. An industry first, Premerus is a nationwide program that dramatically reduces healthcare costs and improves patient care by leveraging the proven advantages of subspecialist expertise to increase diagnostic accuracy.
Local news coverage details concerns about Medicare and Medicaid spending reductions that could affect senior and nursing care.
The End Of Medical Miracles? - Wall Street Journal
In the run up to National Tackling Drugs Week (8th-12th June), drug and alcohol services in Liverpool have gathered together to host "Know more" an event which will showcase a range of services that offer advice and support to young people and their families.
Targeting the issue of low birth rates, the Taiwanese government implemented the Mega Warmth Social Welfare Program (MWSWP) in 2006 after its fertility rates dipped lower than most industrial nations.
Supreme Court nominee Judge Sonia Sotomayor is scheduled to meet with key senators today as Republican leaders indicate that they will try to slow her confirmation process over the summer, the Washington Post reports. Sotomayor, in preparation for her meetings, has been working with White House lawyers to complete a 10-page Senate questionnaire, which aims to reveal details of her legal work, professional associations, personal finances, speeches, and legal and other writings. White House officials said the document will be finished "in the next couple of days." Senate Majority Leader Harry Reid (D-Nev.) said that he will provide Sotomayor"s background information to Republicans "as quickly as possible," adding that he "want[s] to make sure she"s ready to go" when the next Supreme Court term begins in October. Sotomayor is scheduled to meet today with Reid, Senate Minority Leader Mitch McConnell (R-Ky.), Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) and the panel"s ranking member, Jeff Sessions (R-Ala.). She also is scheduled to meet with Sens. Jon Kyl (R-Ariz.), Richard Durbin (D-Ill.), and New York Democrats Charles Schumer and Kirsten Gillibrand, the Post reports.While Sotomayor prepares for her meetings, Republican leaders indicated that they will try to impede President Obama"s push to confirm her before the Senate leaves for summer recess on Aug. 7. McConnell said that the GOP will determine its own schedule regarding Sotomayor"s confirmation, adding that although the GOP will "insist that the confirmation process be conducted in a fair and professional manner, ... respectful doesn"t mean rushed." Senior Senate aides from both parties said that a deal to expedite the confirmation process is unlikely, despite informal negotiations between Sessions and Leahy (Fletcher/Murray, Washington Post, 6/2). Sessions said it would be his "preference" for a confirmation after the August recess but before October. He added that there are "some things that have been raised that we need to explore" and that Sotomayor "deserves an opportunity to deal with the complaints against her" (Rushing, The Hill, 6/1).Conservative Groups Push for Filibuster According to the New York Times "The Caucus," a coalition of conservative groups recently sent a letter to McConnell urging Republicans to filibuster Sotomayor"s confirmation. The letter, which was obtained by the Times, is signed by a range of conservative groups, including antiabortion-rights groups, gun-rights advocates, evangelical leaders and others. Manuel Miranda, a former judicial adviser to former Senate Majority Leader Bill Frist (R-Tenn.), organized the letter. Although Miranda has criticized Democratic filibusters in the past, he said that a Republican filibuster of Sotomayor would help the GOP promote its differences with the Democratic Party on judicial philosophy and the role of the courts. However, Senate Republican leaders thus far have shown little interest in a filibuster, according to the "The Caucus" (Savage, "The Caucus," New York Times, 6/1). The Post reports that the GOP likely does not have enough votes to block Sotomayor"s confirmation with a filibuster, but Republicans could be able to slow the process until September. In this case, Sotomayor still would be able to take her place on the bench when the court reconvenes Oct. 1 (Washington Post, 6/2).The AP/USA Today reports that Republicans are taking a "two-sided strategy" in which they are urging for a respectful debate against Sotomayor while still allowing conservative commentators -- such as Rush Limbaugh and former House Speaker Newt Gingrich (R-Ga.) -- to criticize her, the AP/USA Today reports. By allowing the political attacks from commentators, Republicans who are facing re-election "can avoid potential backlash if they derail a historic nomination," the AP/USA Today reports (AP/USA Today, 6/1).
HHS Secretary Kathleen Sebelius on Friday appointed Cindy Mann, director of Georgetown University"s Center for Children and Families, to head the Center for Medicaid and State Operations, a division of the Centers for Medicare and Medicaid Services, BNA reports. Mann is a former director of the Family and Children"s Health Programs at CMSO from 1999 to 2001. Sebelius said Mann has been "instrumental in recent efforts to expand health care coverage in our country." She added that Mann"s "knowledge of health care issues and management experience will be a great asset to CMSO and to the millions of Americans who rely on Medicaid" (BNA, 6/1).
Two opinion pieces recently responded to criticisms of Judge Sonia Sotomayor, President Obama"s nominee to the Supreme Court.~ Raina Kelley, Newsweek: The "discussions about whether ... Sotomayor was chosen just because she is a Hispanic woman drive me nuts," Newsweek columnist Kelley writes. She continues, "Yes, the fact that she"s a Latina makes a difference in what she brings to the bench, but let"s not overlook the fact that she"d be qualified for the job even if she were a white man." Citing Sotomayor"s experience as a Second Circuit Court of Appeals judge for more than a decade and her educational qualifications as a graduate of Princeton University and Yale Law School, Kelley writes that "we can assume that she has at least some of the appropriate skills to be a Supreme Court justice." She adds, "But when she sits down for those hearings in front of the cameras and the country, the lingering question will still be, "Did she get into all those great schools just because of her race?"" Kelley writes, "It"s infuriating to me that a woman as competent as Sotomayor will have to prove she deserves her nomination while a white-male colleague with the same resume can skip that step and go straight to his judicial philosophy." According to Kelley, "It is time for our hallowed institutions to look like the country" they serve. She notes that "white males have gotten the jobs over at the Supreme Court 96% of the time," concluding that "the assumption that they"re naturally the best candidate for everything, and we"re doing anyone else a favor if we give them a desirable job, is a bit much" (Kelley, Newsweek, 5/29).~ Kathleen Parker, Washington Post: "Even without the help of all those foot soldiers who blast out late-night memos, any sentient being could have predicted the reaction" last week to the nomination of Sotomayor, syndicated columnist Parker writes. She adds, "Within minutes" of the announcement, "a dozen other e-mails tumbled through the hatch enumerating all the reasons Sotomayor was a terrible pick: affirmative action, identity politics, the Ricci [v. DeStefano] case, double standards, racism, sexism." She continues, "Although her judicial record has raised some legitimate concerns, Sotomayor isn"t so easily characterized as the radical liberal that some on the right have suggested. She has ruled favorably toward abortion protesters and unfavorably toward minority plaintiffs." In reference to Sotomayor"s 2001 comments that her experiences as a Hispanic woman might help her reach a ""better conclusion than a white male who hasn"t lived that life,"" Parker asks, "Could a white man get away with saying something comparable about a Latina? Of course not. After Latinas have run the world for 2,000 years, they won"t be able to say it ever again either." Parker continues, "For now, the hot winds of punditry could use a little chill," concluding, "Calling Sotomayor a sexist and racist, far from being fair, is an irrational rush to judgment unbecoming ladies, gentlemen, scoundrels and scholars" (Parker, Washington Post, 5/31).
The World Medical Association has urged the President of Sri Lanka to intervene on behalf of three government employed doctors, two of whom have been detained and the third taken to an unknown destination, after working in the conflict zone in Sri Lanka.
As swine flu spread from Mexico to Texas and then fanned out farther in the United States, Americans began to alter their behavior. Families kept children home from school, postponed trips to the mall, and stayed home instead of eating out. In so doing, the American population may have inadvertently altered the behavior of the pathogen itself.
Revolutionary ultrasonic nanotechnology that could allow scientists to see inside a patient"s individual cells to help diagnose serious illnesses is being developed by researchers at The University of Nottingham.
Mayo Clinic researchers have demonstrated that a noninvasive screening test can detect not only colorectal cancer but also the common cancers above the colon -- including pancreas, stomach, biliary and esophageal cancers. This is one of more than 100 Mayo Clinic studies being presented at Digestive Disease Week 2009 in Chicago, May 30 - June 4.
Merck Sharp & Dohme Limited (MSD) announced that the Medicines and Healthcare products Regulatory Agency (MHRA) has implemented the harmonised Summary of Product Characteristics (SmPCs) for "Cozaar"® (losartan potassium) and "Cozaar"®-Comp (losartan potassium/ hydrochlorothiazide) into the U.K. Marketing Authorisation following a European Commission (EC) Decision.
Secretary of State for work and pensions James Purnell MP is lending his support to an MS Society-led project designed to help people with chronic and fluctuating health conditions remain in work.
Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn"s disease, collectively referred to as IBD.
Researchers are calling for space headache to be established as a new secondary disorder after carrying out a study of 17 astronauts, published in the June issue of Cephalalgia.
The scientific and medical publisher, BMJ Group, is to publish additional themed editions of the British Journal of Sports Medicine (BJSM), supported by the International Olympic Committee (IOC), it was announced today.
America"s chain restaurants are making Americans fatter and sicker say consumer watchdog Center for Science in the Public Interest (CSPI) who
- 1 confirmed case in Wales (a 31 year old male from the Caerphilly local authority area. He has had mild flu symptoms, has been offered antivirals and is recovering at home).
Wireless, personal computers used by cancer patients to log their symptoms help improve the patients" care and further cancer research, according to a study led by researchers in the Duke Comprehensive Cancer Center.
An innovative University of Georgia graduate program in special education that has prepared scores of Georgia teachers to work with elementary-age students with autism over the last several years has received a new 4-year, $793,000 federal grant to train teachers to work with similarly challenged secondary-age students.
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its fully owned subsidiary, BiPar Sciences, announced results from a randomized Phase 2 clinical trial of BSI-201, a poly ADP-ribose polymerase (PARP) inhibitor, in combination with gemcitabine and carboplatin (GC) chemotherapy, in patients with metastatic triple-negative breast cancer (TNBC). BSI-201 is a novel investigational agent that acts by inhibiting PARP1, an enzyme that repairs DNA damage.
Dainippon Sumitomo Pharma Co., Ltd., (DSP) announced that positive results from a phase 2 clinical trial for lurasidone in the treatment of patients with schizophrenia have been published in The Journal of Clinical Psychiatry. This six-week, randomized, double-blind, multicenter, placebo-controlled trial, involving 180 patients with acute schizophrenia, evaluated a single fixed dose of lurasidone 80 mg/day versus placebo. Lurasidone 80 mg/day produced statistically significant improvement versus placebo in both primary and secondary efficacy assessments at all study visits starting at day 3. In addition, lurasidone was generally well-tolerated and was associated with weight and metabolic changes that were similar to placebo.
The United Nations World Food Programme (WFP) announced
Salix Pharmaceuticals, Ltd. (NASDAQ:SLXP) announced on Monday the presentation of new data from its Phase III pivotal clinical trial evaluating the efficacy, safety and tolerability of rifaximin - a non-absorbed (O144. The Effect of Prognostic Factors on the Maintenance of Remission in Hepatic Encephalopathy Patients Treated with Rifaximin
High profile outbreaks associated with the viruses have kept EMSL Analytical scientists busy.
The San Francisco Chronicle reports that Sen. Max Baucus, D-Mont., will meet with supporters of a single-payer health system Wednesday to discuss their ideas on health reform.
"With a health reform at the top of the Congressional and White House agenda, it"s prime time for industry lobbyists," Roll Call reports. But, because details of the anticipated reform package have not yet emerged, industry winners and losers remain largely unknown. Lobbyists are forced to accept clients despite their incomplete knowledge of client needs, and are struggling to anticipate conflicts of interest before they arise, according to the article. "There are so many different players at the table, and right now not knowing whose ox is likely to get gored and at whose expense... the best we can do is try and anticipate conflicts and be clear with our clients in advance," one health care lobbyist told the paper. "We certainly would not lobby on both sides of an issue. It"s also entirely possible conflict may emerge in the next two to six months, and we hope we don"t have to make hard choices" (Ackley, 6/3).
The popular Nintendo Wii videogame system is helping radiology students reach new levels! Faculty from Weill Cornell Medical College have coupled the motion-sensitive Wii remote with the same computers used to analyze scans, and have found that the Wii remote makes examining CT and MRI images more ergonomic, heightens the interactivity during classes, and may potentially improve the ability to interpret scans.
"Advocates for the elderly in California say recent budget cuts are dramatically affecting the ability of social service programs to keep up with demand" at a time when "the state"s elderly population - and the incidents of elder abuse - are exploding," NPR reports. One example is Contra Costa County, where the Aging and Adult Services Program laid off two-thirds of the staff who "investigate abuse complaints of elderly and dependent adults." The county is now "turning over virtually all of its self-neglect cases to some other agency - often, the police." The Contra Costa situation is "so severe that the county grand jury recently concluded that Adult Protective Services no longer has the res to carry out its legal mandate to investigate physical and financial abuse complaints." This comes at a time when complaints of elder abuse are on the rise. According to "national studies," only "1 in 5 elder abuse cases is reported" (Siler, 6/3).
In future, cartilage, tendon and blood vessel tissue will be produced in the laboratory, with cells being grown on a porous frame, such as non-wovens. A new software program helps to characterize and optimize the non-wovens.
University of Queensland scholarship recipient Alex Ridley is using his mathematical and communication skills to improve future public health.
With exciting pre-clinical results showing that its carbohydrate-based vaccine can combat cerebral malaria (CM), which causes inflammation of the brain, Ancora Pharmaceuticals has received another grant from the National Institute of Health (NIH) to research whether its vaccine candidate will also prevent severe malaria anemia (SMA).
TomoTherapy Incorporated (NASDAQ: TOMO) announced that the University of Kentucky (UK) Chandler Medical Center"s Markey Cancer Center has commenced treating patients with the TomoTherapy® Hiò€¢Art® treatment system, a versatile, CT scanner-based device, which integrates image guidance for increased treatment accuracy and helical radiation therapy delivery for enhanced tumor targeting. The Hiò€¢Art treatment system was selected after a thorough review of technologies and will be extensively utilized in the Markey Cancer Center"s stereotactic body radiation therapy (SBRT) efforts, as part of its new Brain and Body Radiosurgery Program.
The Western North Carolina AIDS Project recently launched a media campaign that seeks to raise awareness about the stigma associated with HIV/AIDS and its effect on those living with the virus, as well as the community, the Asheville Citizen-Times reports. The "I Need You to Know" campaign, which will include a set of commercials featuring area residents talking about HIV/AIDS, will serve as a starting point for other prevention efforts (Boyd, Asheville Citizen-Times, 6/3).
A study by neuroscientist Heather Rupp and her team found that a woman"s partner status influenced her interest in the opposite sex. In the studyÂð, published in the March issue of Human Nature, women both with and without sexual partners showed little difference in their subjective ratings of photos of men when considering such measures as masculinity and attractiveness. However, the women who did not have sexual partners spent more time evaluating photos of men, demonstrating a greater interest in the photos. No such difference was found between men who had sexual partners and those who did not.
Researchers at McGill University and the University of Pennsylvania have discovered that a widely used anti-diabetic drug can boost the immune system and increase the potency of vaccines and cancer treatments. Their findings will be published June 3 in the journal Nature.
Interim results from an ongoing phase 2, randomized, placebo-controlled trial of the investigational drug TMC207 for the treatment of multidrug-resistant tuberculosis (MDR-TB) were published in the New England Journal of Medicine. TMC207 is being developed by Tibotec BVBA. The data show that the addition of TMC207 for eight weeks to a 5-drug background regimen, in patients with multidrug-resistant tuberculosis (MDR-TB), resulted in a significant increase in the proportion of patients achieving a negative sputum culture and a shorter time to sputum culture conversion compared with the background regimen alone.
The Premier healthcare alliance has acquired Phase 2 Consulting (P2C), a leading provider of consulting services to hospitals and health systems.
Hip resurfacing can be a good alternative to total hip replacement (THR) in young adults because it conserves bone and it has acceptable short- to medium-term results. However, there have been concerns about fractures of the femoral neck with this procedure, partly due to notching and varus alignment during implantation.
On Wednesday the BMA called on the Scottish Parliament Health Committee to support Government plans to remove the ability for commercial companies to provide NHS general practice services to patients.
A new University of Illinois study of families adopting from foster care revealed significant declines in professional services and social support over the first three years of adoptive family life, even though parents indicated that they need continued assistance.
When added to the mix, a new experimental drug known as TMC207 appeared to make a cocktail of background drugs five times more powerful